CARE Fertility celebrating over 1,000 CAREmaps® babies!
CARE Fertility in Manchester was the first IVF clinic in the UK to introduce EmbryoScope time-lapse imaging for patient use and scientifically devised the CAREmaps® embryo selection system. Since the first baby was born nearly 3 years ago, over 1000 babies have been born across the CARE group. Freya Flatters is the 1000th baby to be born following time-lapse incubation at our London clinic.
Alison Campbell, Director of Embryology at CARE
with Isabella Potter the first CAREmaps® baby
Photo courtesy of Studio 3000
Prof. Simon Fishel with Freya our 1,000th CAREmaps® baby
Photo courtesy of Rebecca Northway
Isabella, the first CAREmaps® baby was born nearly 3 years ago. Freya, is the 1,000th baby to be born using CAREmaps®. Belinda, Freya's mum said "After 4 treatment failures I was emotionally drained and did not know where to go - then we heard about time lapse and CAREmaps®. The method subsequently revealed that certain embryos would have failed."
Prof. Simon Fishel, Founder and President of CARE Fertility said - "With over a 1,000 babies born using this technology, this is a significant milestone in the progress of time lapse imaging and in the practice of human IVF. It is wonderful that so many families are benefitting from this incredible technology.
Success rates are significantly higher with CAREmaps
This table shows the birth rates per embryo transfer for different female age categories for treatment with own eggs between 1/5/11 and 28/2/14 with the number of births and embryo transfers for the review shown in brackets. It compares birth rates for standard practice at CARE with birth rates when using CAREmaps which is an embryo selection method unique to CARE. Birth rates are compared per transfer procedure as CAREmaps is used to select embryos, so applied at the time of transfer.
Time Lapse Embryo Imaging with Embryoscope, CAREmaps at CARE Fertility
Using Time Lapse Embryo Imaging with morphokinetic algorithms (selection models), developed by CARE scientists, we are able to predict which embryos have the highest potential for a successful pregnancy, thereby greatly increasing your chances of having a baby.
The most common reason why IVF fails is chromosomal abnormality (known as 'aneuploidy'). Approximately 70% of embryos produced, either through natural conception or IVF, are lost before birth. A major cause of embryo loss, including miscarriage, is aneuploidy, where there is either a loss or gain of a single chromosome, or complex abnormalities.
Embryologists in routine IVF practice cannot differentiate between chromosomally viable and chromosomally abnormal (aneuploid) embryos and hence aneuploid embryos can unwittingly and inevitably be transferred to the womb, and this will compromise IVF outcome.
This is why CAREmaps is such an exciting and important development. The selection of the most viable embryo using CAREmaps can give you the very best chance of a live birth. CARE Fertility was the first UK clinic to introduce Time Lapse Embryo Imaging and to date we have over 1,000 pregnancies.
CAREmaps is available at all CARE clinics. We will shortly be able to extend the availability through additional CARE locations so please contact CARE - you can leave us your details and we'll advise you as soon as we can if CAREmaps will be available close to you.
What is CAREmaps?
CAREmaps is a whole system designed to maximise the chances of success. CAREmaps includes three important variables which, when used together, enable CARE embryologists to select the most viable embryo to give you the very best chance of a baby.
- Specific morphokinetic algorithms - calculations about what the embryo should be doing at specific points in time
- Time Lapse Embryo Imaging
- Closed incubation
Specific Morphokinetic Algorithms (maps)
These are CARE's calculations about what the embryo should be doing at specific points in time.
Using morphokinetics, combined with genetic information on embryo chromosome numbers, we have developed a risk classification model for aneuploidy so that we can tell whether an embryo has a low, medium or high chance of a live birth.
It is important to note that this is a risk classification - meaning that an embryo is in the high risk group with a low chance of a successful pregnancy, It is not confirming that there is an aneuploidy.
It should be noted that these algorithms apply to CARE's own tried and tested culture conditions and therefore may not be successfully applied at any clinic other than CARE.
The selection of the most viable embryo using CARE maps can give you the very best chance of a healthy live birth.
Time Lapse Embryo Imaging
This allows us to safely and continuously monitor embryos and to observe their developmental patterns closely.
We have observed significant delays in the development of embryos that are aneuploid. This delay is quite subtle and embryologists would not be able to observe it with standard methods of incubation.
The difference between what embryologists can observe with time lapse imaging and standard incubation is precise and significant.
With a 5 day blastocyst embryo the embryologist would observe the following
Standard Incubation requires the removal of the embryos from the incubator to observe them. With time lapse imaging, embryos can remain within the optimum conditions of the incubator.
This provides the optimum, uninterrupted conditions for developing embryos.
A special download
When you use CAREmaps a copy of the Time Lapse video of your embryo developing can be made available for you to view and download following embryo transfer.
What to do next
- Contact CARE - find your nearest CARE clinic here
- Self Referral - you can complete a CARE Fertility Self Referral form here
If you'd like to read our two peer reviewed papers on Time Lapse Embryo Imaging which have been published in the respected journal Reproductive BioMedicine, just click on the links below:
Campbell, A., Fishel, S., Bowman, N., Duffy, S., Sedler, M., Hickman, C.F.L., 2013. Modelling a risk classification of aneuploidy in human embryos using non-invasive morphokinetics. Reproductive BioMedicine Online (2013) 26, 477 - 485
Campbell, A., Fishel, S., Bowman, N., Duffy, S., Sedler, M., Thornton, S., 2013. Retrospective analysis of outcomes after IVF using a time-lapse imaging derived aneuploidy risk model without PGS. Reproductive BioMedicine Online 9 May 2013