Time Lapse Embryo Imaging with Embryoscope, CAREmaps at CARE Fertility

Using Time Lapse Embryo Imaging with morphokinetic algorithms (selection models), developed by CARE scientists, we are able to predict which embryos have the highest potential for a successful pregnancy, thereby greatly increasing your chances of having a baby.

Using CAREmaps, we have demonstrated a 56% uplift in live births2, equivalent to a 78% live birth rate

(based on CARE's Live Birth data)

The most common reason why IVF fails is chromosomal abnormality (known as 'aneuploidy'). Approximately 70% of embryos produced, either through natural conception or IVF, are lost before birth. A major cause of embryo loss, including miscarriage, is aneuploidy, where there is either a loss or gain of a single chromosome, or complex abnormalities.

Embryologists in routine IVF practice cannot differentiate between chromosomally viable and chromosomally abnormal (aneuploid) embryos and hence aneuploid embryos can unwittingly and inevitably be transferred to the womb, and this will compromise IVF outcome.

This is why CAREmaps is such an exciting and important development. The selection of the most viable embryo using CAREmaps can give you the very best chance of a live birth. CARE Fertility was the first UK clinic to introduce Time Lapse Embryo Imaging and to date we have over 1,000 pregnancies.

CAREmaps is available at all CARE clinics. We will shortly be able to extend the availability through additional CARE locations so please contact CARE - you can leave us your details and we'll advise you as soon as we can if CAREmaps will be available close to you.

What is CAREmaps?

CAREmaps is a whole system designed to maximise the chances of success. CAREmaps includes three important variables which, when used together, enable CARE embryologists to select the most viable embryo to give you the very best chance of a baby.

Specific Morphokinetic Algorithms (maps)

These are CARE's calculations about what the embryo should be doing at specific points in time.

Using morphokinetics, combined with genetic information on embryo chromosome numbers, we have developed a risk classification model for aneuploidy so that we can tell whether an embryo has a low, medium or high chance of a live birth.

It is important to note that this is a risk classification - meaning that an embryo is in the high risk group with a low chance of a successful pregnancy, It is not confirming that there is an aneuploidy.

It should be noted that these algorithms apply to CARE's own tried and tested culture conditions and therefore may not be successfully applied at any clinic other than CARE.

The selection of the most viable embryo using CARE maps can give you the very best chance of a healthy live birth.

Time Lapse Embryo Imaging

This allows us to safely and continuously monitor embryos and to observe their developmental patterns closely.

We have observed significant delays in the development of embryos that are aneuploid. This delay is quite subtle and embryologists would not be able to observe it with standard methods of incubation.

The difference between what embryologists can observe with time lapse imaging and standard incubation is precise and significant.




With a 5 day blastocyst embryo the embryologist would observe the following

Standard Incubation requires the removal of the embryos from the incubator to observe them. With time lapse imaging, embryos can remain within the optimum conditions of the incubator.

Closed Incubation

This provides the optimum, uninterrupted conditions for developing embryos.

A special download

When you use CAREmaps a copy of the Time Lapse video of your embryo developing can be made available for you to view and download following embryo transfer.

What to do next




References

If you'd like to read our two peer reviewed papers on Time Lapse Embryo Imaging which have been published in the respected journal Reproductive BioMedicine, just click on the links below:

1Campbell, A., Fishel, S., Bowman, N., Duffy, S., Sedler, M., Hickman, C.F.L., 2013. Modelling a risk classification of aneuploidy in human embryos using non-invasive morphokinetics. Reproductive BioMedicine Online (2013) 26, 477 - 485

CARE Fertility's Risk Classification of Aneuploidy article on Reproductive BioMedicine Online

2Campbell, A., Fishel, S., Bowman, N., Duffy, S., Sedler, M., Thornton, S., 2013. Retrospective analysis of outcomes after IVF using a time-lapse imaging derived aneuploidy risk model without PGS. Reproductive BioMedicine Online 9 May 2013

CARE Fertility's Aneuploidy Risk Model article on Reproductive BioMedicine Online