CARE Fertility pioneered method of Embryo Chromosome Screening is confirmed by ESHRE (European Society for Human Reproduction)

Baby Oliver was the world's first baby to be born following a revolutionary egg screening technique at CARE Fertility in Nottingham. Since his landmark birth in 2009, this type of screening using Array CGH has transformed the care of women suffering from repeated pregnancy loss and IVF treatment failure. A new, multi-centre, proof of principle study carried out by The European Society for Human Reproduction [ESHRE] has replicated the UK-pioneered method and confirmed its accuracy.

Dr Simon Fishel
Professor Simon Fishel

Professor Simon Fishel, Managing Director of CARE Fertility Group said "Our goal at CARE is to improve the success of IVF treatment. We know that chromosomal abnormality has a huge impact on establishing a successful pregnancy. This latest European study confirms CARE's pioneering work from 2008 and validates the accuracy of this type of screening"

"We know that up to half of the eggs in younger women and up to 75% in older women are chromosomally abnormal. With the method we used for Oliver's mum, a biopsy is taken of the polar body inside the egg. Array CGH is used to evaluate all of the chromosomes in a single cell and select the most chromosomally normal embryos"

The unfertilised egg has a polar body and the newly fertilised egg produces another. By assessing both polar bodies the ESHRE study confirmed that the egg can accurately predict the chromosome status of the embryo 94% of the time.

Simon Fishel says "CARE further developed this work and is able to offer array CGH to patients to screen eggs &embryos at various stages of development up to 5 or 6 days after fertilisation, as well as eggs, giving a much wider option for our patients"

Dr Simon Fishel

The patients who have already benefited from Array CGH include those where the woman is 36 years of age or older, couples suffering recurrent miscarriage or repeated IVF treatment failure or couples who already have a child with a chromosome abnormality. Comment from a new mum, a media professional from London.

"After 7 unsuccessful cycles of back to back ivf over two long years and with 19 'good-looking' embryos transferred, I began to wonder if my dream of becoming a mother would ever come true. Then I heard of array cgh and two cycles and six months later I became pregnant in the knowledge that my eggs had been screened and aged 43 I gave birth to my beautiful, healthy baby girl. To me, ivf without array cgh is like playing roulette - you just don't know whether you are putting normal or abnormal embryos inside you - there is no correlation between the way they look and whether they are chromosomally normal or not. With array cgh you have a far greater chance of success - I am thankfully testament to that.

The ESHRE study evaluated 42 cycles of treatment and acknowledged the UK work by CARE scientists. Including baby Oliver, 467 Array CGH cycles have now been carried out at CARE Fertility Group.

Click to view The Case Report produced by Simon Fishel et al