If you’ve experienced more than one miscarriage, or if you've been through two or more unsuccessful IVF treatments, we’re likely to recommend recurrent implantation failure screening.
There are a number of tests we can use to try and understand the cause or causes of failed implantations, and which we use will depend on our understanding of you and what we suspect could be the problem. When we have your results we should then be able to offer some additional advanced procedures that could help to improve your chances.
During the last ten years we've done a lot of work to try and identify reasons for IVF failure and miscarriage.
Chromosomal problems in the embryos seem to be a major factor, and to see whether this could be the issue for you we might suggest pre-implantation genetic screening, which helps us to choose embryos with the best chromosomes for implantation.
Aside from chromosomal abnormalities, other causes for failed implantation relate to problems with the woman’s hormones, blood clotting or immune system, all of which can prevent embryos from implanting properly. It’s these kinds of problems that we check for during recurrent implantation failure screening.
There are a number of techniques and tests we can use to see why you might be struggling. Some key tests might include:
By screening for particular antibodies and autoantibodies, we can get an insight into whether your immune system could be preventing embryos from implanting properly.
C4M2 is the name of a gene mutation that can be carried by both men and women, and if passed to an embryo it can cause both failed implantation and miscarriage. Our pioneering scientists were the first in the world to discover that this can be treated with heparin, which if you or your partner are a carrier can improve your chances of success.
Both sperm DNA damage and chromosomal disorders can be a cause of recurrent implantation failure, so if you’re having trouble we could recommend screening for one or both of these problems.