Recurrent Miscarriage and Implantation Failure

If you’ve had IVF treatment previously that hasn’t been successful or if you have experienced recurrent miscarriage, CARE can hopefully help you.

We understand how painful failed treatment and miscarriage can be and we know how important it is to identify the reasons why this is happening before deciding how to progress with future treatment. There are a number of tests allowing us to create a tailored treatment plan that could improve your chances of success.

There are a number of ways that we investigate recurrent miscarriage or repeated treatment failure where a good quality embryo has failed to attach and implant into the uterus (known as implantation failure).

Who can be helped by investigations and treatments for recurrent implantation failure and miscarriage?

At CARE we think you might benefit from specialist investigations if you have:

  • Had two or more consecutive miscarriages or two or more failed IVF cycles (especially after a transfer of an embryo known to have the usual number of chromosomes following PGT-A testing)
  • Miscarried a baby where tissue analysis showed there were no chromosomal abnormalities 
  • An existing autoimmune illness (rheumatoid arthritis, lupus, Crohn’s disease, thyroid illness or psoriasis for example)
  • Had previous pregnancies where you had a small for dates baby (known as fetal growth restriction) or significant pre-eclampsia (high blood pressure in pregnancy).

What are the causes of recurrent implantation failure and miscarriage?

Sadly, there are likely to be many reasons why an embryo doesn’t attach in the uterus or miscarries in early pregnancy. Medical science has yet to help us fully understand all the possible reasons but in general terms miscarriage or implantation failure can arise either because the embryo is not viable or because the environment of the uterus isn’t as it should be.

 

The embryo

We do know from scientific evidence that genetic abnormalities in embryos increase with the age of the egg provider. It is also possible for a perfectly healthy person to have rearrangements in their chromosomes that don’t cause any problems for them, but cause serious genetic imbalances in embryos created with their eggs or sperm. Genetic abnormalities can lead to failed implantation and miscarriage. 

 

The endometrium

The conditions in the uterus have to be just right for an embryo to implant. 

 

How are these possible causes of implantation failure or miscarriage investigated?

We do two levels of tests to investigate possible causes of implantation failure or miscarriage, these include tests for chromosomal abnormalities, CAREunity and DNA damage or oxidative stress in the sperm.

If you would like more information on any of these tests and to find out if they are suitable for you, you will be able to discuss with your doctor at your consultation. We also have detailed Patient Information documents on all of our tests and treatments.