PGT-M for single gene disorders involves testing embryos created through in vitro fertilization (IVF) and then transferring unaffected embryos.
Pre-implantation Genomic Testing is for people who are concerned about passing an inherited disease or condition, like cystic fibrosis, beta thalassaemia and Fanconi anaemia, onto their children. You won’t necessarily have fertility problems, though if needed we can help with these too.
PGT-M was formerly known as PGD or Preimplantation Genetic Diagnosis. Since PGD was first licensed by the Human Fertilisation and Embryology Authority (HFEA) the list of genetic conditions we can test for has been growing steadily. PGT-M can now be performed for almost any single gene disorder with an identified mutation and availability of appropriate family members. If you’re wondering whether you can have PGT-M for an illness affecting you or your partner, we can provide you with a complete list of licensed conditions. If your condition isn’t on this list, we’ll investigate whether we can develop a test for it and then ask the HFEA for approval.
You may consider PGT-M if:
PGT-M tests are created uniquely for each family. PGT-M can be performed for nearly any single gene disorder as long as the specific familial mutation has been identified and appropriate family members are available for test preparation
It is one of the best techniques available to assist in identifying and avoiding certain genomic diseases, and allows your baby to have a healthy start.
Multiple pregnancy is the main risk associated with PGT-M, however it can be reduced by having a single embryo transfer. At CARE, the safety of our patients is key to everything we do and because the risk of complications is higher in a twin pregnancy we recommend single embryo transfer where we can. This has resulted in our multiple pregnancy rates being among the lowest in the UK, whilst maintaining among the highest success rates. If you have any additional, unaffected embryos from your treatment then they can be kept frozen for possible transfer in the future.