ZyMot is a device, also called a chip, which can be used in the IVF laboratory to prepare and select sperm for insemination by intracytoplasmic sperm injection (ICSI). ZyMot relies on the sperm actively swimming through the membrane filter in the chip, demonstrating motility.
This technology is designed to mimic aspects of natural conception and avoids centrifugation which some reports suggest may stress the sperm membranes and potentially cause damage.
We require a minimum of 1 million progressively motile sperm per ml to be able to use the ZyMot for ICSI, therefore samples with lower numbers of motile sperm, or with very poor motility, will need to be prepared using the conventional method. If you request the use of ZyMot, an embryologist will be able to advise on the day of your ICSI treatment if ZyMot cannot be used, and any fees for this will be refunded.
ZyMot is relatively new so there is not a large amount of evidence available to support its use and confirm the benefits which have been reported by several research and clinical teams.
We have reviewed the recent scientific literature (2017-2020) relating to ZyMot and concluded the following:
The low number of small and differing studies are limitations of our analysis and data from one study was used twice in this analysis. Therefore, more high-quality studies to investigate the effects of microfluidic sperm selection on sperm parameters and reproductive outcomes need to be conducted.
We have achieved successful fertilisation, embryo development and pregnancies with ZyMot at CARE Fertility and our scientists are fully trained and competent to use the chips.