Male IVF diagnostic tests

Male fertility problems can be due to a number of issues and diagnosis usually involves a general physical examination and semen analysis. We can offer cutting edge tests too, which check for chromosomal issues, or sperm DNA damage. 

You can read more about these tests below.

Hormone screening

Hormone screening and testing can give us an indication of everything from how many sperm you’re able to produce, to whether you might have an underlying medical condition – and all of this information will help us to give you the right fertility treatment. 

Could testing my hormones be for me?

If you’re a new patient or suffering from unexplained fertility problems we’re likely to suggest hormone screening, as it can really help us to better understand your needs.

In men, particular hormones can be good indicators of how much sperm you’re able to produce.

What does hormone screening involve?

The levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in your blood can help us get an idea of how much sperm you might be producing. We’ll also check your testosterone levels.

Multiple Ejaculation Resuspension and Centrifugation (MERC) test

MERC lets us detect sperm in semen samples even when numbers are low.

Our scientists introduced the MERC technique so that, when our patients have a low sperm count or reportedly no sperm, we can try to find sperm in multiple semen samples to use in fertility treatment and avoid the need for surgery.

Could MERC be right for me?

If you’ve been told you’re producing little or no sperm in your ejaculate, we could recommend MERC as a way of collecting sperm for treatment. If it’s not successful you might then go ahead with surgical sperm retrieval.

What does MERC involve?

For the MERC test we’ll need you to provide us with several semen samples in one day – usually around three samples with two hours left between each.
Once you’ve given us the samples we’ll process them, finding any sperm that could be used in fertility treatment. If we identify sperm in your samples we might then freeze them to use in future treatments.

Semen analysis

The quality of your sperm is really important in deciding your next steps.

Male fertility problems are one of the largest known causes of infertility in couples – in fact, they contribute to up to 30%–50% of cases. Sperm analysis is essential to both diagnosis and treatment, so when you come to us, your sperm is one of the first things we’ll need to check.

Could semen analysis be right for me?

Whether or not you’re generally healthy or have had a child before, we’ll always recommend semen analysis to every man that comes to CARE. When couples are struggling to start a family around 30% of cases are related to sperm, so it’s essential we see whether this is a possibility.

We’d usually book you in for semen analysis before your first consultation or as part of a fertility assessment. That way, the results will be ready when you meet your consultant.

What does semen analysis involve?

Before the sperm test, you’ll need to abstain from sex for three to five days. When we test your semen sample, we’ll assess:

  • Volume
  • Number of sperm
  • Sperm motility, looking at how well they’re swimming
  • Shape, size, and appearance – or morphology - of the sperm
  • Presence of white or red blood cells
  • Whether there’s an immune response, known as anti-sperm antibodies, against sperm proteins.

Sperm chromosome screening

Genetically testing your sperm can help us better decide your next steps.

Research suggests that low sperm motility, low sperm count and poor sperm shape could be related to chromosomal disorders. Screening your sperm lets us check for these kinds of anomalies and whether they could be passed on to an embryo.

Could sperm chromosome screening be right for me?

Problems with your sperm chromosomes can cause miscarriages or serious genetic conditions and illnesses in children, so if we think your sperm might have any chromosome disorders we’ll encourage you to be tested.

We’ll usually recommend sperm chromosome screening as an additional male fertility test for:

  • Couples with repeated miscarriages or implantation failure
  • Couples with previously low or failed fertilisation following IVF
  • Men who have normal chromosome patterns but whose embryos have chromosomal problems
  • Men with a low sperm count
  • Men over 50.
What does sperm screening involve?

For screening, we simply need you to provide a semen sample. We’ll then freeze your sample and test it for abnormalities, and results should be available within a few weeks. Once we have the results, together we’ll discuss your next steps, which could be further tests or possible treatments.

SOS (Sperm Oxidative Stress) test

High levels of oxidative stress could be a cause of lower pregnancy rates and a higher risk of miscarriage.

Excess oxidative stress in the body has been linked to abnormal sperm morphology and motility, as well as sperm DNA and cell membrane damage, contributing to poor sperm function, abnormal semen analysis results, and failed IVF outcomes. DNA damage within sperm cells could result in DNA errors within an embryo, in turn potentially contributing to lower pregnancy rates and a higher risk of miscarriage.

What is oxidative stress?

Highly reactive molecules called free radicals are produced as a by-product of our cells using oxygen to produce energy, and though these free radicals usually perform vital functions for our health, such as fighting infection, too many can be very damaging. Antioxidants produced by the body counteract these free radicals, keeping the system in balance, but when the production of free radicals exceeds the body’s production of antioxidants, the excess free radicals can cause damage to tissues such as proteins, cell membranes and the DNA of cells, including sperm. This is called oxidative stress.

Who should be tested for oxidative stress?

We may recommend a SOS (Sperm Oxidative Stress) test as an additional male fertility test for:

  • Partners of women with a history of two or more pregnancy losses
  • Males over the age of 40
  • Males with suboptimal semen analysis results (particularly low morphology or motility)
  • Males with poor lifestyle, body mass index over 30, who smoke, have high alcohol intake or poor diet.
What does the SOS test involve?

For SOS screening, we simply need you to provide a semen sample. We’ll then analyse the sample in our laboratory, assessing the balance of free radicals and antioxidants in the sperm. This test can be done at the same time as a semen analysis test, or at any point in your treatment. Once we have the results, we’ll discuss your best next steps with you, which could be further tests or possible treatments.

Sperm DNA damage screening

Sperm DNA damage could be a cause of low quality sperm.

Factors including your age and lifestyle can damage your sperm DNA. So, if you’re over 50 years old, you’re a current or ex-smoker, or if you could have been exposed to glue vapours or other toxicants that can affect your fertility, it might be a good idea to have your sperm checked for DNA damage.

Could sperm DNA screening be right for me?

We’re most likely to recommend sperm DNA damage screening if you’re struggling with:

  • Unexplained or persistent infertility
  • Low fertilisation rates or poor embryo quality in IVF cycles
  • Recurrent implantation failure
  • Recurrent miscarriage
What does sperm DNA screening involve?

For screening, we simply need you to provide a semen sample. We’ll then freeze your sample and ship this over to our laboratory, where it will be thawed and tested for DNA damage.
Once we have the results, together we’ll discuss your next steps, which could be further tests or possible treatments.